Associate Scientist/Scientist I, Translational Biology
Cambridge, MA USA · Alewife, Cambridge · USD 88,000-144,000 · 3+ years experience · Onsite · Posted Sep 29, 2026
At a glance
- Experience
- 3+ years experience
- Workplace
- Onsite
- Location
- Cambridge, MA USA · Alewife, Cambridge
- Salary
- USD 88,000-144,000 · Base salary
About the role
- The Associate Scientist/Scientist I will serve as a subject-matter expert in flow cytometry and ex vivo tissue processing within the translational biology team.
- This role involves executing complex multi-parameter panels and tissue isolation workflows to evaluate lipid nanoparticle (LNP) delivery and therapeutic function.
- The position contributes to high-throughput discovery workflows at the intersection of biology, automation, and AI while mentoring junior team members.
Responsibilities
- Independently execute high-dimensional, multi-parameter flow cytometry panels to assess LNP uptake, expression, and immune activation.
- Own the full flow cytometry workflow including instrument setup, spectral unmixing, acquisition, and data analysis in FlowJo.
- Isolate viable single-cell suspensions from liver, spleen, and whole blood across mouse, rat, NHP, and human samples.
- Prepare tissues for downstream analysis including homogenization, protein/RNA extraction, and lysate preparation.
- Drive flow-based readouts for LNP and delivery system performance across species and tissues.
- Execute high-throughput, plate-based screening experiments and contribute to screening design.
- Oversee sample collection, labeling, and biorepository integrity.
- Assist with development of multiplex immunoassays such as MSD, Luminex, and ELLA.
- Analyze, interpret, and present experimental data to inform project direction.
- Maintain detailed laboratory notebooks and mentor junior staff on technical best practices.
Requirements
- B.S. with 5+ years or M.S. with 3+ years of hands-on laboratory experience in Biology, Immunology, or related field.
- Advanced expertise in multi-parameter flow cytometry, including panel design and spectral unmixing.
- Hands-on experience with FlowJo for gating and multi-parameter data analysis.
- Demonstrated expertise in ex vivo tissue processing and cell isolation from liver, spleen, and blood.
- Experience with primary cell culture and immortalized cell lines.
- Ability to independently manage and prioritize multiple concurrent experiments.
- Strong organizational skills and commitment to data integrity.
- Proficiency with electronic lab notebook keeping.
Preferred qualifications
- Industry experience
- Experience with high-parameter conventional or spectral platforms
- Hands-on expertise with multiplex immunoassay platforms (MSD, Luminex, ELLA)
- Working knowledge of nucleic acid therapeutics or LNPs
- Experience processing tissues for biodistribution or tissue-resident immune cell analysis
- Hands-on experience with qPCR or ddPCR
- Experience coordinating studies with CROs
- Experience with automation and liquid handlers
Benefits
- Competitive base compensation
- Bonus potential
- Early-stage equity
- Medical, dental, and vision coverage
- Employer-paid life and disability insurance
- Flexible time off
- Paid parental leave
- Educational assistance program
- Commuter benefits
- Company subsidized lunch program
Workplace
- Located in Alewife, Cambridge, MA.
- Company subsidized lunch program for office-based employees.
Skills
- Flow Cytometry
- FlowJo
- Tissue Processing
- Cell Isolation
- Spectral Flow Cytometry
- Multiplex Immunoassays
- MSD
- Luminex
- ELLA
- IncuCyte
- Liquid Handling
- qPCR
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- ddPCR
- ELISA
- FACS
