Biological Scientist

Rockville · Axle Informatics LLC · USD 110,000-120,000 · 2+ years experience · Posted Oct 9, 2026

At a glance

Axle is seeking a Biological Scientist to join our vibrant team at the National Institutes of Health (NIH) supporting the National Institute of Allergy and Infectious Diseases (NIAID) located in Bethesda, MD.
The role involves coordinating structural biology core requests, determining three-dimensional structures of HIV-1 envelope glycoproteins, and collaborating with regulatory and clinical teams.

Coordinate intake and prioritization of Structural Biology Core (SBC) requests from VRC cores and sections for structural characterization of viral proteins, immunogens, or vaccine-elicited antibodies.
Coordinate handoffs across the SBC structural biology pipeline, tracking timelines at each stage and facilitating scheduling of shared structural biology resources and instrumentation.
Serve as point of contact between the Structural Biology Core and other VRC cores and sections to relay structural findings that inform immunogen design iterations or manufacturing decisions.
Maintain records of solved structures, deposition status, and associated metadata for internal reference and manuscript preparation.
Compile structural biology progress updates for inclusion in SBC joint meetings with VRC labs, program milestone reports, and regulatory nonclinical summaries.
Determine and analyze three-dimensional structures of HIV-1 envelope glycoproteins and antibodies, with or without additional ligands.
Express and purify or coordinate distribution of purified proteins from eukaryotic expression systems.
Perform or coordinate immunogenicity studies in small animals.
Crystallize or utilize cryo-EM technologies for structure determination of antibodies and HIV-1 glycoproteins.
Prepare text, tables, and figures for manuscripts for publication.

PhD in Biology or a related field is required.
Minimum of 2+ years of experience with manufacturing/clinical trials is required.